In vitro gastrointestinal digestion of a bisdemethoxycurcumin-rich Curcuma longa extract and its oral bioavailability in rats

Abstract Background Nonetheless curcumin has potential health benefits, its low bioavailability limits the application of conventional turmeric extract with as major curcuminoid. This is a comparative study to assess stability, bioaccessibility and biological activity BDMC in standardized C. longa (REVERC3) relative regular (RTE). Here we report preparation Curcuma (REVERC3™) contain 75 ± 5 w/w % bisdemethoxycurcumin (BDMC), 1.2 0.8 10 demethoxycurcumin (DMC). The extracts were subjected vitro gastrointestinal digestion curcuminoids undigested digested samples analyzed using HPLC determine bioaccessibility. Further, evaluated for lipase inhibition antioxidant activities. Male Wistar rats administered single dose (1000 mg/kg) RTE plasma concentration respectively at different time points LCMS/MS. Results was significantly higher than ( p < 0.05). found superior having significant inhibitory effect 0.01), ABTS radical scavenging 0.05), nitric oxide activities 0.01). Interestingly, 18.76 compared curcumin. C max 4.4-fold Conclusion reported have Our findings rationalize use BDMC-enriched improved physiological benefits counteracting less bioavailable